Combining Microdosing (LSD and Psilocybin) with Medications and Supplements

Dr. James Fadiman, PhD, and Sophia Korb, PhD, have thoughtfully curated a list encompassing medications, supplements, and drugs that, through their research, have shown no adverse side effects when used alongside microdosing.

To quickly search this list for your medication, use CNTRL + F (on PC) or COMMAND + F (on Mac) and type in your medication.

Painkillers

• Acetomenophen/Paracetemol (Tylenol)
• Aspirin
• Codeine
• Dihydrocodeine (Co-dydramol)
• Hydrocodone (Vicodin, Norco)
• Ibuprofen (Advil, Motrin)
• Naproxen (Aleve)

– Do not microdose while taking Tramadol

Heart/high blood pressure medication

• Amiodarone (Cordarone, Nexterone)
• Hydrochlorothiazide (HCTZ, HCT)
• Lisinopril (Prinivil, Zestril)
• Losartan (Cozaar)
• Spironolactone (Aldactone)
• Telemisartin (Micardis, Actavis)
• Valsartan (Diovan)

Birth-control

• Aubra
• Hormonal pills
• Marvelon
• Mirena
• Nuvaring
• Tricyclen

Antacid

• Ranitidine (Zantac)

Antibiotics

• Clindamycin (Cleocin, Dalacin, Clinacin)
• Doxycycline
• Minocycline (Minocin, Minomycin, Akamine)
• Penicillin (Bicillin)

Antifungals

• Fluconazole (Diflucan, Celozole)

Focus medication (ADHD/ADD)

• Amphetamine (Adderall)
• Bupropion (Wellbutrin)
• Dextroamphetamine (Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa)
• Lisdexamfetamine (Vyvanse)
• Methylphenidate (Ritalin, Biphentin)
• Modafinil (Provigil)

Sleeping

• Zopiclone (Zimovane, Imovane)
• Melatonin
• Zolpidem (ambien, stilnox)

Antihistamines

• Cetirizine (Zyrtec)
• Diphenahydramine (Benadryl, Gravol)
• Loratadine (Claritin)
• Ranitidine (Zantac)

Benzodiazepines (anxiety, sleep, seizure)

• Alprazolam (Xanax)
• Clonazepam (Klonopin)
• Diazepam (Valium)
• Flurazepam (Staurodorm)
• Lorazepam (Ativan)

Other anxiolytic

• Etizolam
• Propranolol

Parkinson’s medication

• Levodopa
• Pramipexole

Cholesterol medication

• Atorvastatin (Lipitor)
• Rosuvastatin (Crestor)
• Simvastatin (Zocor)
• Statins

Racetams

• Aniracetam
• Phenylpiracetam
• Piracetam

Mood stabilizers and antipsychotics

• Aripiprazole (Abilify)
• Buspirone (Buspar)
• Lamotrigine (Lamictal)
• Quetiapine (Seroquel)

– Do not microdose while taking Lithium

Diabetes

• Metformin (Glucophage)

Anticonvulsants

• Baclofen (Lioresal)
• Carbamazepine (Tegretol)
• Cyclobenzaprine (Flexeril)
• Gabapentin
• Mirtazapine
• Sodium valproate
• Tizanidine (Zanaflex)

Thyroid medication

• Methimazole or Thiamazole

Antidepressants

• Bupropion (Wellbutrin)
• Citalopram (Celexa)
• Desvenlafaxine (Pristiq)
• Doxepin (Sinequan)
• Duloxetine (Cymbalta)
• Escitalopram (Lexapro)
• Paroxetine (Paxil)
• Sertraline (Zoloft)
• Venlafaxine (Effexor)

GERD

• Esomeprazole (Nexium)
• Pantoprazole (Protonix)
• Ranitidine (Zantac)

Breathing (asthma, COPD)

• Salbutamol (Albuterol)
• Cetirizine (Zyrtec)
• Beclometasone (Clenil Modulite)
• Montelukast (Singulair)

Antiviral

• Nitazoxanide

Recreational drugs

• Alcohol
• Amphetamine (speed)
• Heroin
• Kratom
• Marijuana (cannabis)
• Nicotine

Anti-inflammatory

• Mesalazine (Octasa)

Immunosuppressant

• Hydroxychloroquine (Quensyl)

Erectile Dysfunction

• Tadalafil (Cialis)

Alcohol dependence treatment

• Acamprosate (Campral)
• Disulfiram (Antabuse)
• Naltrexone

Hormones and Steroids

• Norethindrone Acetate ethinyl
• Estradiol
• Prednisone (Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone)
• Estrogen (Premarin)
• Progesterone (Prometrium, Utrogestan, Endometrin)
• Testosterone
• Levothyroxine (Synthroid)
• Naturethroid
• Dexamethasone

DHEA

• spironolactone (Aldactone)

Supplements

• 5-HTP
• Albizia
• Ashwagandha
• B100
• BCAAs
• Biotin
• Brahmi
• Bromelain
• Caffeine
• Calcium
• Cayenne
• Chaga
• Chlorophyll
• Choline
• CILTEP
• CoQ10
• Cordyceps
• Creatine
• Eleuthero
• EPA/DHA
• Fish oil
• Ginseng
• Glucosamine
• Iodine
• Iron
• Kelp
• Kratom
• L-theanine
• Lemon balm
• Lion’s Mane
• Maca
• Magnesium
• MCT
• Methyl sulfonyl methane (MSM)
• Milk thistle
• Multivitamins
• Mmega 3/6/9
• Passionflower
• Phosphatidyl
• Probiotics
• Pycnogenol
• Reishi
• Rhodiola
• Rosacea
• Selenium
• Shatavari
• Skullcap
• Johns wort
• Taurine
• Tulsi
• Turmeric (curcumin)
• Turkey’s tail
• Twynsta
• Vitamin
  • B6
  • B12
  • D3
  • K
  • C
  • K2
  • D
• Zinc
• Zinium

New added: 

• Ramipril
• primidone (anti convulsant)
• topiramate (anti convulsant)

It’s imperative to clarify that while this list offers valuable insights, it does not provide an absolute guarantee of safety when combining microdosing with any of the mentioned medications or supplements. The nuanced interactions between substances and the human body can vary widely, and caution must always be exercised.

A Prudent Approach

When considering the integration, cessation, or adjustment of medications in conjunction with microdosing, a few essential principles should be adhered to:

Consult Your Healthcare Professional

Prior to making any decisions, it’s vital to engage in a conversation with your healthcare provider. They possess the expertise and knowledge necessary to evaluate your unique situation.

Exercise Due Diligence

Keep in mind that the field of microdosing is continually evolving, and comprehensive data on interactions with medications are limited. Hence, no one is currently equipped with enough information to provide definitive guidance on this matter.

Informed Decision-Making

If you contemplate reducing or discontinuing medication in favor of microdosing, ensure that it aligns with your healthcare objectives. Undertake thorough research to weigh the potential benefits and risks associated with such a decision.

In summary, while the synergy between microdosing and medications or supplements is a subject of intrigue, it’s a terrain where caution, medical consultation, and meticulous research should always guide one’s choices. Your health and well-being are paramount, and decisions in this realm should reflect a judicious and informed approach.